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Loravan generic. Price of loravan. Uses, Dosage, Side effects
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What is Loravan
Loravan indications
How should I use Loravan
Uses of Loravan in details
Loravan description
Loravan dosage
Loravan interactions
Loravan side effects
Loravan contraindications
Active ingredient matches for Loravan
List of Loravan substitutes (brand and generic names)
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LoRaWAN® | The Things Network
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Loravan Price Comparison: Uses, Dosage, Form & Side Effects
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Loravan generic. Price of loravan. Uses, Dosage, Side effects
Loravan Uses What is the dose of your medication? 1-5mg 6-10mg 11-50mg 51-100mg 101-200mg 201-500mg 501mg-1g sponsored Uses Dosage Side effects Pregnancy Overdose Actions Loravan indications
Uses of Loravan in details
Loravan description
Loravan dosage
Loravan interactions
Loravan side effects
Loravan contraindications What is Loravan? Loravan injection is used before certain medical procedures, such as surgery, to relieve anxiety. When Loravan is used before surgery, the patient will not remember some of the details about the procedure. Loravan is also used to treat certain convulsive (seizure) disorders, such as epilepsy. Loravan is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system. Loravan is available only with your doctor’s prescription. Loravan indications An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician. sponsored
Status Epilepticus Loravan Injection is indicated for the treatment of status epilepticus. Preanesthetic Loravan Injection is indicated in adult patients for preanesthetic medication, producing sedation (sleepiness or drowsiness), relief of anxiety, and a decreased ability to recall events related to the day of surgery. It is most useful in those patients who are anxious about their surgical procedure and who would prefer to have diminished recall of the events of the day of surgery. How should I use Loravan? Use Loravan solution as directed by your doctor. Check the label on the medicine for exact dosing instructions. Loravan solution is usually given as an injection at your doctor’s office, hospital, or clinic. If you will be using Loravan solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Loravan solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use Loravan solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Loravan solution should not be injected into an artery because serious side effects may occur.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you miss a dose of Loravan solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Ask your health care provider any questions you may have about how to use Loravan solution. Uses of Loravan in details There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Anxiety (oral): Management of anxiety disorders or short-term (≤4 months) relief of anxiety.
Procedural anxiety, premedication (injection): Anesthesia premedication in adults to relieve anxiety or to produce amnesia (diminish recall) or sedation.
Status epilepticus (injection): Treatment of status epilepticus. May be used off label for acute seizures that have not yet progressed to status epilepticus.
Off Label Uses
Akathisia, antipsychotic-induced
Data from a limited number of open-label clinical trials suggest that Loravan may be beneficial for the treatment of patients with antipsychotic-induced akathisia.
Loravan description
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem]
Loravan dosage
Recommended Dosage
Initiate Loravan in patients who are being treated with Loravan tablets, administered three times daily in evenly divided doses (refer to the Prescribing Information of Loravan tablets for the recommended dosage of Loravan tablets).
Discontinue Loravan tablets and administer the first dose of Loravan in the morning the day after the final dose of Loravan tablets.
The recommended once daily dosage of Loravan is equal to the total daily dose of Loravan tablets. For example, the recommended dosage for patients who have been receiving Loravan tablets at a dosage of 1 mg three times daily is Loravan 3 mg once daily in the morning.
The effectiveness of Loravan use for more than 4 months has not been assessed in clinical studies. Healthcare providers should periodically re-evaluate longer term use of Loravan.
Administration Information
Administer Loravan orally once daily, in the morning, with or without food. Do not crush or chew Loravan.
Swallow Loravan capsules whole or open the capsule and sprinkle the entire contents over a tablespoon of applesauce, followed by drinking water. Consume all the sprinkled Loravan in its entirety, (without chewing) within 2 hours; do not store for future use.
Dosage Increase for Inadequate Clinical Response
If the clinical response to Loravan is inadequate and a dosage increase in needed, discontinue Loravan and switch to Loravan tablets to increase the dosage. If an adequate clinical response is achieved with a stable, evenly divided three times daily dosage of Loravan tablets, resume Loravan once daily dosing with the total daily dose of Loravan tablets.
Discontinuation or Dosage Reduction of Loravan
To reduce the risk of withdrawal reactions, use a gradual taper to discontinue Loravan or reduce the dosage. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Subsequently decrease the dosage more slowly.
Concomitant Use with UDP-glucuronosyltransferase (UGT) Inhibitors
If an UGT inhibitor is initiated during treatment with Loravan, discontinue Loravan and switch to Loravan tablets to reduce the dosage.
Loravan interactions
See also:
What other drugs will affect Loravan?
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Loravan Injection, like other injectable benzodiazepines, produces additive depression of the central nervous system when administered with other CNS depressants such as ethyl alcohol, phenothiazines, barbiturates, MAO inhibitors, and other antidepressants.
When scopolamine is used concomitantly with injectable Loravan, an increased incidence of sedation, hallucinations and irrational behavior has been observed.
There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and Loravan.
Marked sedation, excessive salivation, ataxia, and, rarely, death have been reported with the concomitant use of clozapine and Loravan.
Apnea, coma, bradycardia, arrhythmia, heart arrest, and death have been reported with the concomitant use of haloperidol and Loravan.
The risk of using Loravan in combination with scopolamine, loxapine, clozapine, haloperidol, or other CNS-depressant drugs has not been systematically evaluated. Therefore, caution is advised if the concomitant administration of Loravan and these drugs is required.
Concurrent administration of any of the following drugs with Loravan had no effect on the pharmacokinetics of Loravan: metoprolol, cimetidine, ranitidine, disulfiram, propranolol, metronidazole, and propoxyphene. No change in Loravan dosage is necessary when concomitantly given with any of these drugs.
Loravan-Valproate Interaction
Concurrent administration of Loravan (2 mg intravenously) with valproate (250 mg twice daily orally for 3 days) to 6 healthy male subjects resulted in decreased total clearance of Loravan by 40% and decreased formation rate of Loravan glucuronide by 55%, as compared with Loravan administered alone. Accordingly, Loravan plasma concentrations were about two-fold higher for at least 12 hours post-dose administration during valproate treatment. Loravan dosage should be reduced to 50% of the normal adult dose when this drug combination is prescribed in patients.
Loravan-Oral Contraceptive Steroids Interaction
Coadministration of Loravan (2 mg intravenously) with oral contraceptive steroids (norethindrone acetate, 1 mg, and ethinyl estradiol, 50 μg, for at least 6 months) to healthy females (n=7) was associated with a 55% decrease in half-life, a 50% increase in the volume of distribution, thereby resulting in an almost 3.7-fold increase in total clearance of Loravan as compared with control healthy females (n=8). It may be necessary to increase the dose of Loravan in female patients who are concomitantly taking oral contraceptives.
Loravan-Probenecid Interaction
Concurrent administration of Loravan (2 mg intravenously) with probenecid (500 mg orally every 6 hours) to 9 healthy volunteers resulted in a prolongation of Loravan half-life by 130% and a decrease in its total clearance by 45%. No change in volume of distribution was noted during probenecid co-treatment. Loravan dosage needs to be reduced by 50% when coadministered with probenecid.
Drug/Laboratory Test Interactions
No laboratory test abnormalities were identified when Loravan was given alone or concomitantly with another drug, such as narcotic analgesics, inhalation anesthetics, scopolamine, atropine, and a variety of tranquilizing agents.
Loravan side effects
See also:
What are the possible side effects of Loravan?
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Status Epilepticus
The most important adverse clinical event caused by the use of Loravan Injection is respiratory depression.
The adverse clinical events most commonly observed with the use of Loravan Injection in clinical trials evaluating its use in status epilepticus were hypotension, somnolence, and respiratory failure.
INCIDENCE IN CONTROLLED CLINICAL TRIALS
All adverse events were recorded during the trials by the clinical investigators using terminology of their own choosing. Similar types of events were grouped into standardized categories using modified COSTART dictionary terminology. These categories are used in the table and listings below with the frequencies representing the proportion of individuals exposed to Loravan Injection or to comparative therapy.
The prescriber should be aware that these figures cannot be used to predict the frequency of adverse events in the course of usual medical practice where patient characteristics and other factors may differ from those prevailing during clinical studies. Similarly, the cited frequencies cannot be directly compared with figures obtained from other clinical investigators involving different treatment, uses, or investigators. An inspection of these frequencies, however, does provide the prescribing physician with one basis to estimate the relative contribution of drug and nondrug factors to the adverse event incidences in the population studied.
COMMONLY OBSERVED ADVERSE EVENTS IN A CONTROLLED DOSE-COMPARISON CLINICAL TRIAL
Table 1 lists the treatment-emergent adverse events that occurred in the patients treated with Loravan Injection in a dose-comparison trial of Loravan 1 mg, 2 mg, and 4 mg.
TABLE 1. NUMBER (%) OF STUDY EVENTS IN A DOSE COMPARISON CLINICL TRIAL Body System Event Loravan Injection (n=130)* * One hundred and thirty (130) patients received Loravan Injection. † Totals are not necessarily the sum of the individual study events because a patient may report two or more different study events in the same body system. Any Study Event (1 or more)† 16 (12.3%) Body as a whole Infection 1 ( <1%) Cardiovascular system Hypotension 2 (1.5%) Digestive system Liver function tests abnormal 1 ( <1%) Nausea 1 ( <1%) Vomiting 1 ( <1%) Metabolic and Nutritional Acidosis 1 ( <1%) Nervous system Brain edema 1 ( <1%) Coma 1 ( <1%) Convulsion 1 ( <1%) Somnolence 2 (1.5%) Thinking abnormal 1 ( <1%) Respiratory system Hyperventilation 1 ( <1%) Hypoventilation 1 ( <1%) Respiratory failure 2 (1.5%) Terms not classifiable Injection site reaction 1 ( <1%) Urogenital system Cystitis 1 ( <1%) In two studies, patients who completed the course of treatment for status epilepticus were permitted to be reenrolled and to receive treatment for a second status episode, given that there was a sufficient interval between the two episodes. Safety was determined from all treatment episodes for all intent-to-treat patients, i.e., from all “patient-episodes.” Table 2 lists the treatment-emergent adverse events that occurred in at least 1% of the patient-episodes in which Loravan Injection or diazepam was given. The table represents the pooling of results from the two controlled trials. TABLE 2. NUMBER (%) OF STUDY EVENTS IN ACTIVE CONTROLLED CLINICAL TRIAL Body System Event Loravan Injection (n=85)* Diazepam (n=80)* * The number indicates the number of “patient-episodes.” Patient-episodes were used rather than “patients” because a total of 7 patients were reenrolled for the treatment of a second episode of status: 5 patients received Loravan Injection on two occasions that were far enough apart to establish the diagnosis of status epilepticus for each episode, and, using the same time criterion, 2 patients received diazepam on two occasions. † Totals are not necessarily the sum of the individual study events because a patient may report two or more different study events in the same body system. Any Study Event (1 or more)† 14 (16.5%) 11 (13.8%) Body as a whole Headache 1 ( 1.2%) 1 (1.3%) Cardiovascular system Hypotension 2 (2.4%) 0 Hemic and lymphatic system Hypochromic anemia 0 1 (1.3%) Leukocytosis 0 1 (1.3%) Thrombocythemia 0 1 (1.3%) Nervous system Coma 1 (1.2 %) 1 (1.3%) Somnolence 3 (3.5%) 3 (3.8%) Stupor 1 (1.2%) 0 Respiratory system Hypoventilation 1 (1.2%) 2 (2.5%) Apnea 1 (1.2%) 1 (1.3%) Respiratory failure 2 (2.4%) 1 (1.3%) Respiratory disorder 1 (1.2%) 0 These trials were not designed or intended to demonstrate the comparative safety of the two treatments. The overall adverse experience profile for Loravan was similar between women and men. There are insufficient data to support a statement regarding the distribution of adverse events by race. Generally, age greater than 65 years may be associated with a greater incidence of central-nervous-system depression and more respiratory depression. OTHER EVENTS OBSERVED DURING THE PRE-MARKETING EVALUATION OF Loravan Injection FOR THE TREATMENT OF STATUS EPILEPTICUS Loravan Injection, active comparators, and Loravan Injection in combination with a comparator were administered to 488 individuals during controlled and open-label clinical trials. Because of reenrollments, these 488 patients participated in a total of 521 patient-episodes. Loravan Injection alone was given in 69% of these patient-episodes (n=360). The safety information below is based on data available from 326 of these patient-episodes in which Loravan Injection was given alone. All adverse events that were seen once are listed, except those already included in previous listings (Table 1 and Table 2). Study events were classified by body system in descending frequency by using the following definitions: frequent adverse events were those that occurred in at least 1/100 individuals; infrequent study events were those that occurred in 1/100 to 1/1000 individuals. Frequent and Infrequent Study Events BODY AS A WHOLE - Infrequent: asthenia, chills, headache, infection. DIGESTIVE SYSTEM - Infrequent: abnormal liver function test, increased salivation, nausea, vomiting. METABOLIC AND NUTRITIONAL - Infrequent: acidosis, alkaline phosphatase increased. NERVOUS SYSTEM - Infrequent: agitation, ataxia, brain edema, coma, confusion, convulsion, hallucinations, myoclonus, stupor, thinking abnormal, tremor. RESPIRATORY SYSTEM - Frequent: apnea; Infrequent: hyperventilation, hypoventilation, respiratory disorder. TERMS NOT CLASSIFIABLE - Infrequent: injection site reaction. UROGENITAL SYSTEM- Infrequent: cystitis. Preanesthetic The most frequent adverse drug event reported with injectable Loravan is central-nervous-system depression. The incidence varied from one study to another, depending on the dosage, route of administration, use of other central-nervous-system depressants, and the investigator’s opinion concerning the degree and duration of desired sedation. Excessive sleepiness and drowsiness were the most common consequences of CNS depression. This interfered with patient cooperation in approximately 6% (25/446) of patients undergoing regional anesthesia, causing difficulty in assessing levels of anesthesia. Patients over 50 years of age had a higher incidence of excessive sleepiness or drowsiness when compared with those under 50 (21/106 versus 24/245) when Loravan was given intravenously. On rare occasion (3/1580) the patient was unable to give personal identification in the operating room on arrival, and one patient fell when attempting premature ambulation in the postoperative period. Symptoms such as restlessness, confusion, depression, crying, sobbing, and delirium occurred in about 1.3% (20/1580). One patient injured himself by picking at his incision during the immediate postoperative period. Hallucinations were present in about 1% (14/1580) of patients and were visual and self-limiting. An occasional patient complained of dizziness, diplopia and/or blurred vision. Depressed hearing was infrequently reported during the peak-effect period. An occasional patient had a prolonged recovery room stay, either because of excessive sleepiness or because of some form of inappropriate behavior. The latter was seen most commonly when scopolamine was given concomitantly as a premedicant. Limited information derived from patients who were discharged the day after receiving injectable Loravan showed one patient complained of some unsteadiness of gait and a reduced ability to perform complex mental functions. Enhanced sensitivity to alcoholic beverages has been reported more than 24 hours after receiving injectable Loravan, similar to experience with other benzodiazepines. LOCAL EFFECTS Intramuscular injection of Loravan has resulted in pain at the injection site, a sensation of burning, or observed redness in the same area in a very variable incidence from one study to another. The overall incidence of pain and burning in patients was about 17% (146/859) in the immediate postinjection period and about 1.4% (12/859) at the 24-hour observation time. Reactions at the injection site (redness) occurred in approximately 2% (17/859) in the immediate postinjection period and were present 24 hours later in about 0.8% (7/859). Intravenous administration of Loravan resulted in painful responses in 13/771 patients or approximately 1.6% in the immediate postinjection period, and 24 hours later 4/771 patients or about 0.5% still complained of pain. Redness did not occur immediately following intravenous injection but was noted in 19/771 patients at the 24-hour observation period. This incidence is similar to that observed with an intravenous infusion before Loravan is given. Intra-arterial injection may produce arteriospasm resulting in gangrene which may require amputation. CARDIOVASCULAR SYSTEM Hypertension (0.1%) and hypotension (0.1%) have occasionally been observed after patients have received injectable Loravan. RESPIRATORY SYSTEM Five patients (5/446) who underwent regional anesthesia were observed to have airway obstruction. This was believed due to excessive sleepiness at the time of the procedure and resulted in temporary hypoventilation. In this instance, appropriate airway management may become necessary. OTHER ADVERSE EXPERIENCES Skin rash, nausea and vomiting have occasionally been noted in patients who have received injectable Loravan combined with other drugs during anesthesia and surgery. Paradoxical Reactions As with all benzodiazepines, paradoxical reactions such as stimulation, mania, irritability, restlessness, agitation, aggression, psychosis, hostility, rage, or hallucinations may occur in rare instances and in an unpredictable fashion. In these instances, further use of the drug in these patients should be considered with caution. Postmarketing Reports Voluntary reports of other adverse events temporally associated with the use of Loravan Injection that have been received since market introduction and that may have no causal relationship with the use of Loravan Injection include the following: acute brain syndrome, aggravation of pheochromocytoma, amnesia, apnea/respiratory arrest, arrhythmia, bradycardia, brain edema, coagulation disorder, coma, convulsion, gastrointestinal hemorrhage, heart arrest/failure, heart block, liver damage, lung edema, lung hemorrhage, nervousness, neuroleptic malignant syndrome, paralysis, pericardial effusion, pneumothorax, pulmonary hypertension, tachycardia, thrombocytopenia, urinary incontinence, ventricular arrhythmia. Fatalities also have been reported, usually in patients on concomitant medications (e.g., respiratory depressants) and/or with other medical conditions (e.g., obstructive sleep apnea). Loravan contraindications See also: What is the most important information I should know about Loravan? Do not use this medication if you are allergic to Loravan or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax). This medication can cause birth defects in an unborn baby. Do not use Loravan if you are pregnant. Before taking Loravan, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol. Do not drink alcohol while taking Loravan. This medication can increase the effects of alcohol. Avoid using other medicines that make you sleepy. They can add to sleepiness caused by Loravan. Loravan may be habit-forming and should be used only by the person it was prescribed for. Loravan should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. It is dangerous to try and purchase Loravan on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of Loravan purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide. Active ingredient matches for Loravan: Lorazepam in Thailand. Unit description / dosage (Manufacturer) Price, USD Loravan 0.5 mg x 500's Loravan 1 mg x 500's List of Loravan substitutes (brand and generic names): Lorativan LORAVIN (India) LORAVIN tab 1 mg x 10's (Archicare) LORAVIN tab 2 mg x 10's (Archicare) LORAWEL LORAWEL 1MG TABLET 1 strip / 10 tablets each (Sigmund Promedica) $ 0.26 LORAWEL 2MG TABLET 1 strip / 10 tablets each (Sigmund Promedica) $ 0.33 LORAWEL INJECTION 1 vial / 2 ML injection each (Sigmund Promedica) $ 0.23 Lorawel 2mg Tablet (Sigmund Promedica) $ 0.03 Lorawel 2mg Injection (Sigmund Promedica) $ 0.12 Lorax (Brazil) 10's (Pax Healthcare) $ 0.95 Lorax Lornoxicam 8 mg, Paracetamol500 mg. TAB / 10 (Pax Healthcare) $ 0.95 LORAX 1MG TABLET 1 strip / 10 tablets each (Pax Healthcare) $ 0.17 LORAX 2MG TABLET 1 strip / 10 tablets each (Pax Healthcare) $ 0.27 LORAX tab 10's (Pax Healthcare) $ 0.95 Lorax 1mg Tablet (Pax Healthcare) $ 0.02 Lorax 2mg Tablet (Pax Healthcare) $ 0.03 LORAZ (THEO) LORAZ 1MG TABLET 1 strip / 10 tablets each (Theo Pharma Pvt Ltd) $ 0.24 LORAZ 2MG TABLET 1 strip / 10 tablets each (Theo Pharma Pvt Ltd) $ 0.32 LORAZAM (India) 1 mg x 10's (Invision (Marx)) $ 0.24 2 mg x 10's (Invision (Marx)) $ 0.41 Lorazam 1mg TAB / 10 (Invision (Marx)) $ 0.24 Lorazam 2mg TAB / 10 (Invision (Marx)) $ 0.41 LORAZAM tab 1 mg x 10's (Invision (Marx)) $ 0.24 LORAZAM tab 2 mg x 10's (Invision (Marx)) $ 0.41 Lorazam 1mg TAB / 10 (Invision (Marx)) $ 0.24 Lorazam 2mg TAB / 10 (Invision (Marx)) $ 0.41 Lorazemed (Belgium) LORAZEN LORAZEN INJECTION 1 vial / 2 ML injection each (Zenith Healthcare Ltd) $ 0.23 LORAZEN TABLET 1 strip / 10 tablets each (Zenith Healthcare Ltd) $ 0.16 Lorazen NA Tablet (Zenith Healthcare Ltd) $ 0.02 Lorazep (Thailand) Lorazep 0.5 mg x 1, 000's (Asian Pharm) $ 9.09 Lorazep 1 mg x 1, 000's (Asian Pharm) $ 12.12 Lorazep 2 mg x 1, 000's (Asian Pharm) $ 18.18 Lorazep tab 0.5 mg 1000's (Asian Pharm) $ 9.09 Lorazep tab 1 mg 1000's (Asian Pharm) $ 12.12 Lorazep tab 2 mg 1000's (Asian Pharm) $ 18.18 Lorazepam (Australia, Bahrain, Canada, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, India, Ireland, Malta, Mexico, New Zealand, Nicaragua, Pakistan, Panama, Peru, Slovenia, South Africa, South Korea, Taiwan, United Kingdom, United States, Venezuela) Tablet; Oral; Lorazepam 1 mg Tablet; Oral; Lorazepam 2 mg Tablet; Oral; Lorazepam 0.5 mg Injectable; Injection; Lorazepam 2 mg / ml Injectable; Injection; Lorazepam 4 mg / ml Solution; Oral; Lorazepam 0.5 mg / 5 ml Concentrate; Oral; Lorazepam 2 mg / ml See 1036 substitutes for Loravan References DailyMed. "LORAZEPAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018). PubChem. "lorazepam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018). DrugBank. "lorazepam". http://www.drugbank.ca/drugs/DB00186 (accessed September 17, 2018). Reviews User reports Consumer reported useful No survey data has been collected yet Report useful » Consumer reported price estimates No survey data has been collected yet Report price estimates » 1 consumer reported time for results To what extent do I have to use Loravan before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Loravan. To get the time effectiveness of using Loravan drug by other patients, please click here. Users % 1 day 1 100.0% Report time for results » As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Loravan. To get the time effectiveness of using Loravan drug by other patients, please click here. 4 consumers reported age Users % 16-29 2 50.0% 30-45 2 50.0% Report age » Consumer reviews There are no reviews yet. Be the first to write one! Your name: Email: Spam protection: < Type 25 here Information checked by Dr. Sachin Kumar, MD Pharmacology
LoRaWAN®
Welcome to The Things Fundamentals on LoRaWAN!
This series of chapters was created to prepare you for The Things Fundamentals certification. You’ll learn all about LoRa® and LoRaWAN and suitable use cases, and afterwards you’ll be ready to start developing your own LoRaWAN applications.
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Loravan Price Comparison: Uses, Dosage, Form & Side Effects
Home Loravan Did you experience any side effects after consuming the medication? No Yes advertisement Here is the some steps to help you to save money on Loravan purchase. Read drug prescription
What is Loravan
Loravan side effects
Loravan dosing
Select the most affordable brand or generic drug
Frequently asked Questions
How should I take Loravan?
Who should not take Loravan?
What other drugs will affect Loravan?
Loravan reviews
Read drug prescription It is very important to know about what medicine is given by the doctor, for what condition, and when it needs to be taken in what dose. This information given by the doctor is called Prescription. The patients should be familiar with the medicine prescription, and the details about the medicine before purchasing it and using it. Some medications need not be prescribed by healthcare practitioners and can be purchased and used without prescription by the patients; these are called over-the-counter medications. Read the drug prescription information of Loravan before taking it.
What is Loravan Loravan is in a group of drugs called benzodiazepines. Loravan affects chemicals in the brain that may become unbalanced and cause anxiety.
Loravan is used to treat anxiety disorders.
Loravan may also be used for other purposes not listed in Loravan guide.
Loravan side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
confusion, depressed mood, thoughts of suicide or hurting yourself;
hyperactivity, agitation, hostility;
hallucinations; or
feeling light-headed, fainting.
Less serious side effects may include:
drowsiness, dizziness, tiredness;
blurred vision;
sleep problems ;
muscle weakness, lack of balance or coordination;
amnesia or forgetfulness, trouble concentrating;
nausea, vomiting, constipation;
appetite changes; or
skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
advertisement Loravan dosing Usual Adult Dose for ICU Agitation: IV, intermittent:
Initial dose: 1 to 4 mg IV every 10 to 20 minutes to Loravan acute agitation.
Maintenance dose: 1 to 4 mg IV every 2 to 6 hours and as needed to maintain desired level of sedation.
IV, continuous infusion:
0.01 to 0.1 mg/kg/hr IV to maintain desired level of sedation.
High-dose infusions have been associated with tubular necrosis, lactic acidosis and hyperosmolality states due to the polyethylene glycol and propylene glycol solvents.
Usual Adult Dose for Anxiety: Oral:
Initial dose: 1 mg orally 2 to 3 times a day.
Maintenance dose: 1 to 2 mg orally 2 to 3 times a day. The daily dosage may vary from 1 to 10 mg/day orally.
IV:
Alternatively, an initial intravenous dose of 2 mg or 0.044 mg/kg, whichever is smaller, may be given.
Usual Adult Dose for Insomnia: 2 to 4 mg orally at bedtime
Usual Adult Dose for Light Anesthesia: Premedication for Anesthesia:
IM: 0.05 mg/kg up to a maximum of 4 mg.
IV: 2 mg total, or 0.044 mg/kg, whichever is smaller.
This dose should not ordinarily be exceeded in patients over 50 years of age.
Larger doses as high as 0.05 mg/kg up to a total of 4 mg may be administered.
Usual Adult Dose for Nausea/Vomiting: Oral or IV: 0.5 to 2 mg every 4 to 6 hours as needed
Usual Adult Dose for Status Epilepticus: 4 mg/dose slow IV over 2 to 5 minutes ; may repeat in 10 to 15 minutes; usual total maximum dose: 8 mg
Usual Pediatric Dose for Nausea/Vomiting — Chemotherapy Induced: Children: IV: Limited information exists, especially for multiple doses:
Single dose: 0.04 to 0.08 mg/kg/dose prior to chemotherapy (maximum dose: 4 mg)
Multiple doses: Some centers use 0.02 to 0.05 mg/kg/dose (maximum dose: 2 mg) every 6 hours as needed
Usual Pediatric Dose for Anxiety: Infants and Children: Usual: 0.05 mg/kg/dose every 4 to 8 hours; range: 0.02 to 0.1 mg/kg
Usual Pediatric Dose for Sedation: Sedation (preprocedure): Infants and Children:
Oral, IM, IV: Usual: 0.05 mg/kg; range: 0.02 to 0.09 mg/kg
IV: May use smaller doses (e.g., 0.01 to 0.03 mg/kg) and repeat every 20 minutes, as needed to titrate to effect
Usual Pediatric Dose for Status Epilepticus: Infants and Children: 0.05 to 0.1 mg/kg slow IV over 2 to 5 minutes (maximum rate: 2 mg/minute); may repeat every 10 to 15 minutes if needed.
Adolescents: 0.07 mg/kg (maximum: 4 mg/dose) slow IV over 2 to 5 minutes (maximum rate: 2 mg/minute); may repeat in 10 to 15 minutes if needed; usual total maximum dose: 8 mg. Loravan is in a group of drugs called benzodiazepines. Loravan affects chemicals in the brain that may become unbalanced and cause anxiety.is used to treat anxiety disorders.Loravan may also be used for other purposes not listed in Loravan guide.Get emergency medical help if you have any of thesehives; difficulty breathing; swelling of your face, lips, tongue, or throat.Call your doctor at once if you have any of these serious side effects:Less serious side effects may include:This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.Side effects (in more detail)IV, intermittent:Initial dose: 1 to 4 mg IV every 10 to 20 minutes to Loravan acute agitation.Maintenance dose: 1 to 4 mg IV every 2 to 6 hours and as needed to maintain desired level of sedation.IV, continuous infusion:0.01 to 0.1 mg/kg/hr IV to maintain desired level of sedation.High-dose infusions have been associated with tubular necrosis, lactic acidosis and hyperosmolality states due to the polyethylene glycol and propylene glycol solvents.Initial dose: 1 mg orally 2 to 3 times a day.Maintenance dose: 1 to 2 mg orally 2 to 3 times a day. The daily dosage may vary from 1 to 10 mg/day orally.IV:Alternatively, an initial intravenous dose of 2 mg or 0.044 mg/kg, whichever is smaller, may be given.2 to 4 mg orally at bedtimePremedication for Anesthesia:IM: 0.05 mg/kg up to a maximum of 4 mg.IV: 2 mg total, or 0.044 mg/kg, whichever is smaller.This dose should not ordinarily be exceeded in patients over 50 years of age.Larger doses as high as 0.05 mg/kg up to a total of 4 mg may be administered.Oral or IV: 0.5 to 2 mg every 4 to 6 hours as needed4 mg/dose slow IV over 2 to 5 minutes ; may repeat in 10 to 15 minutes; usual total maximum dose: 8 mgChildren: IV: Limited information exists, especially for multiple doses:Single dose: 0.04 to 0.08 mg/kg/dose prior to chemotherapy (maximum dose: 4 mg)Multiple doses: Some centers use 0.02 to 0.05 mg/kg/dose (maximum dose: 2 mg) every 6 hours as neededInfants and Children: Usual: 0.05 mg/kg/dose every 4 to 8 hours; range: 0.02 to 0.1 mg/kgSedation (preprocedure): Infants and Children:Oral, IM, IV: Usual: 0.05 mg/kg; range: 0.02 to 0.09 mg/kgIV: May use smaller doses (e.g., 0.01 to 0.03 mg/kg) and repeat every 20 minutes, as needed to titrate to effectInfants and Children: 0.05 to 0.1 mg/kg slow IV over 2 to 5 minutes (maximum rate: 2 mg/minute); may repeat every 10 to 15 minutes if needed.Adolescents: 0.07 mg/kg (maximum: 4 mg/dose) slow IV over 2 to 5 minutes (maximum rate: 2 mg/minute); may repeat in 10 to 15 minutes if needed; usual total maximum dose: 8 mg. Active ingredients: Lorazepam
Select the most affordable brand or generic drug Generic drug is the basic drug with an active substance in it, and the name of the generic drug is same as active substance most of the times. Like Acetaminophen/Paracetemol is Generic name and it has different brand names like Tylenol, Acimol, Crocin, Calpol etc. All these Brand names contain the same Paracetemol, but the medications are manufactured by different companies, so the different brand names. Generic drug is always cheaper and affordable, and it can be replaced in place of brand name drug prescribed by the healthcare practitioner. The Generic medicine has same properties as branded medicine in terms of uses, indications, doses, side effects, so no need to worry on that. Just select the most affordable generic or branded medicine.
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References
Dailymed.”Lorazepam: dailymed provides trustworthy information about marketed drugs in the united states. dailymed is the official provider of fda label information (package inserts).”. https://dailymed.nlm.nih.gov/dailym… (accessed August 28, 2018). “Lorazepam”. https://pubchem.ncbi.nlm.nih.gov/co… (accessed August 28, 2018). “Lorazepam”. http://www.drugbank.ca/drugs/DB0018… (accessed August 28, 2018).
Loravan – Frequently asked Questions
Can Loravan be stopped immediately or do I have to stop the consumption gradually to ween off?
In some cases, it always advisable to stop the intake of some medicines gradually because of the rebound effect of the medicine.
It’s wise to get in touch with your doctor as a professional advice is needed in this case regarding your health, medications and further recommendation to give you a stable health condition.
How should I take Loravan?
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Measure the liquid form of Loravan with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Loravan should be used for only a short time. Do not take this medication for longer than 4 months without your doctor’s advice.
Loravan may be habit-forming and should be used only by the person it was prescribed for. Loravan should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Contact your doctor if this medicine seems to stop working as well in treating your symptoms.
Do not stop using Loravan suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.
Your symptoms may return when you stop using Loravan after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Loravan. Withdrawal symptoms may include tremor, sweating, muscle cramps, stomach pain, vomiting, unusual thoughts or behavior, and seizure.
To be sure this medication is not causing harmful effects, your doctor may need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.
Store Loravan at room temperature away from moisture, heat, and light.
Store the liquid form of Loravan in the refrigerator.
Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Who should not take Loravan?
It is dangerous to try and purchase Loravan on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of Loravan purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide.
Do not use this medication if you have narrow-angle glaucoma, or if you are allergic to Loravan or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), or oxazepam (Serax).
Before taking Loravan, tell your doctor if you are allergic to any drugs, or if you have:
glaucoma;
asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
kidney or liver disease;
a history of depression or suicidal thoughts or behavior; or
a history of drug or alcohol addiction.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.
FDA pregnancy category D. Loravan can cause birth defects in an unborn baby. Do not use Loravan without your doctor’s consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth Loravan while you are using this medication.
It is not known whether Loravan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
The sedative effects of Loravan may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking Loravan.
Do not give this medication to a child younger than 12 years old.
What other drugs will affect Loravan?
Before taking Loravan, tell your doctor if you are using any of the following drugs:
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or
antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).
This list is not complete and there may be other drugs that can interact with Loravan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Can Loravan be taken or consumed while pregnant?
Please visit your doctor for a recommendation as such case requires special attention.
Can Loravan be taken for nursing mothers or during breastfeeding?
Kindly explain your state and condition to your doctor and seek medical advice from an expert.
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Reviews
Patient reports
Patient reported useful No survey data has been collected yet
Report useful »
Patient reported side effects No survey data has been collected yet
Report side effects »
Patient reported price estimates No survey data has been collected yet
Report price estimates »
One patient reported frequency of use How often should I take Loravan?
According to the survey, gmedication.com reported that users of Loravan should take Once in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here. Patients % Once in a day 1 100.0%
Report frequency of use » According to the survey, gmedication.com reported that users of Loravan should take Once in a day as the primarily recommended frequency. However, patients are advised to follow the dosage as prescribed by their physician religiously. To get the opinions of other patients on the ideal consumption frequency of the medicine, click here.
Two patients reported doses What is the specific doses you have used?
Loravan May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient’s condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses. Patients % 1-5mg 1 50.0% 6-10mg 1 50.0%
Report doses » Loravan May come in various doses. In most cases, antibiotics, antihypertensive, pain killers and anti-diabetic drugs available in different doses. Your doctor may prescribe any of the doses based on the severity of the patient’s condition. According to our reports, users of gmedication.com used the drugs in the following dosage percentage (Provide dosage percentage). Only a handful of drugs are made in a single or fixed dose. Regular health conditions like fever have similar doses. For instance [acetaminophen, 500mg] was used by the patients surveyed although it comes in different doses.
Patient reported time for results No survey data has been collected yet
Report time for results »
Patient reported administration No survey data has been collected yet
Report administration »
One patient reported age Patients % > 60 1 100.0%
Report age »
Patient reviews
There are no reviews yet. Be the first to write one!
Your name: Email: Spam protection: < Type 25 here The information was verified by Dr. Vishal Pawar, MD Pharmacology
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