Top 18 How Much Valium Can Kill You The 30 Detailed Answer

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How much Valium can you take in a day?

Adults—10 milligrams (mg) 3 or 4 times for the first 24 hours, then 5 mg 3 to 4 times per day as needed. Older adults—At first, 2 to 2.5 mg 1 or 2 times a day. Your doctor will gradually increase your dose as needed. Children—Use and dose must be determined by your doctor.

What doses does Valium come in?

Valium is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg diazepam.

How long is Valium effective?

The effects of Valium last around 4-6 hours; however it has a very long half life (20-70 hours – time taken to clear 50% of the drug from the body) which means that it may take up to six weeks to be totally excreted by the body.

Is 5mg of Valium enough?

Generally, whether Valium is used to treat anxiety, muscle spasms or seizures, they are supposed to take between 2 to 10 milligrams (mg) up to four times a day. When they exceed those dosage limits and take it more often than necessary, that’s when Valium use becomes too much.

How long does 5mg diazepam last?

Response and effectiveness. The peak effects of diazepam are seen within 1 to 1.5 hours in most people. Diazepam is metabolized to active metabolites and its effects may last for more than 24 hours and extend with repeated dosing as the drug accumulates in the body.

How long does it take for a 5mg diazepam to work?

How long does diazepam take to start working? Diazepam starts to work very quickly in your body, and you should get calming effects within two hours of taking it.

Is 5mg diazepam side effects?

Drowsiness, dizziness, tiredness, blurred vision, or unsteadiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.

Is diazepam 5 mg a sleeping pill?

Diazepam is a benzodiazepine sleeping pill. It is also known by the trade names Dialar, Diazemuls, Diazepam Desitin, Diazepam Rectubes, Stesolid and Tensium.

Fake Valium Warning: It Can Kill You

Can Valium Kill You? | American Council on Science and Health

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Summary of article content: Articles about Can Valium Kill You? | American Council on Science and Health In two case studies of suice attempts using Valium, one person took 500 mg, and another took 2000 mg. Depending on the dosage, the number of … …
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Valium (Diazepam Tablets): Uses, Dosage, Side Effects, Interactions, Warning

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Most searched keywords: Whether you are looking for Valium Use: How Much Is ‘Too Much’? | Serenity at Summit Updating Valium is a potent benzodiazepine capable of producing dependence and addiction. When combined with alcohol and other drugs, Valium can be deadly. If you believe you are taking too much Valium, then professional treatment can help. Visit our site to learn more.
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What Is Valium

Is Valium Safe

How Much Valium Can You Take

The Dangers Effects and Symptoms of Valium

Too Much Valium and Addiction

Professional Addiction Treatment

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Summary of article content: Articles about Can A Valium Overdose Kill You? How Much Valium Warrants A Trip To The ER? | Addiction & Recovery medical answers | Emotional & Mental Health center | SteadyHealth.com The lethal dose of Valium in 50 percent of the population is 720mg per kilogram in mice and 1240mg per kilogram in rats. A human being would … …
Most searched keywords: Whether you are looking for Can A Valium Overdose Kill You? How Much Valium Warrants A Trip To The ER? | Addiction & Recovery medical answers | Emotional & Mental Health center | SteadyHealth.com The lethal dose of Valium in 50 percent of the population is 720mg per kilogram in mice and 1240mg per kilogram in rats. A human being would … Valium, which is the first brand name for the benzodiazepine drug diazepam, is prescribed to patients for its sedating and calming effect.
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Can Valium Kill You?

This graph is a lie. But it’s a lie of omission and it’s misleading, because anyone examining this graph would conclude that people all of sudden started dropping dead from Valium (and other benzodiazepines) (1). Except they haven’t.

The current masochistic war on drugs, uh, make that Americans, doesn’t just pertain to Vicodin or Percocet. Getting a scheduled drug (like a sedative) is enough to make you need a sedative. In New York, you can’t get a prescription for a restricted drug even one day early (2). If you’re going to run out of Ambien (3) in the middle of your planned vacation, you may be S.O.L. (4). But enough about this.

The graph is not there simply to debunk a myth (5), but rather as a teaching tool for one of the main tenets of pharmacology—drug-drug interactions (6). This explains why Valium is sometimes dangerous and sometimes not.

First, the word benzodiazepine is thrown around a lot. I would be remiss in my duty as a chemist (7) if I didn’t try to make at least some sense out of it.

The chemical structure of Valium. The red circle contains a 7-membered ring having two nitrogen atoms (a diazapine). The green circle contains a benzene ring. When fused with another ring (sharing a bond between them) the term benzo is used. All benzodiazepines contain this fused two-ring structure, and differ only by the absence or presence other atoms (e.g., the chlorine).

The term “drug-drug interaction” itself is misleading, which is why most people think that if you take a bunch of different medicines they somehow find each other in your body and do icky things to you. Not true. What really happens is that one drug will do something to the body—usually to the liver—that alters the blood level of the second drug, making them either higher or lower. Although there is no easy way to predict this a priori , there are easy lab tests to let you know early if this is going to be a problem with the drug you are trying to discover. There are also a few generalities. Certain drugs, especially, anti-fungal medications are notorious for affecting the levels of other drugs you might be taking (8).

For example, the common antifungal drug Diflucan (fluconazole) (9) comes with a list of 651 (!!) other drugs that it interacts with, including asthma drugs, antidepressants, antihistamines, cholesterol medications, analgesics… many more. You can add 900 dietary supplements and herbal remedies to that list as well. Some of these interactions are very dangerous. People have died from taking fluconazole with certain HIV drugs, antibiotics, and ulcer drugs, among others.

The mechanism by which these effects take place is similar to the reason that Valium can either deadly or safe—inhibition or induction of a critical class of liver enzymes called cytochrome P450 (CYPs). CYPs are ubiquitous, and have been found in all living organisms. There are an enormous number of subtypes (called isotypes), and they exist for one primary reason—metabolism, especially redox reactions.

The x-ray crystallographic structures of a CYP protein (left) and the same protein bound to an antifungal drug (right). The drug is shown in blue and red. Note that the drug fits tightly into a cleft of the protein, turning it “off.”

Source: PLOS

If one or more of the CYPs are inhibited by drugs, much higher, even lethal, levels of a normally safe drug can result. So can lower levels if the CYPs are activated, but this is less common. This is what really happens in a drug-drug interaction.

It is also one reason why Valium may or may not be deadly. In two case studies of suicide attempts using Valium, one person took 500 mg, and another took 2000 mg. Depending on the dosage, the number of pills consumed ranged from 50-400. (To put this in perspective, if you take that many aspirin, Advil, Tylenol, or NoDoz pills, you will end up being quite dead. Although both patients went into what was termed a “moderately deep coma,” each of them woke up and were released from the hospital within two days. Clearly, Valium is a poor choice for suicide. It is too safe.

But not when you add alcohol. Unlike the anti-fungals alcohol does not strongly inhibit multiple CYPs; the effect is still there- just more subtle. One CYP isoform is called CYP2C19 and it plays a part in the metabolic fate of both alcohol and Valium, but in different ways. Alcohol is an inhibitor of CYP2C19 (Source: Adverse Drug Interactions: A Handbook for Prescribers), and Valium is a substrate of it (is metabolized by it). This means that the metabolism and thus, elimination of Valium will be slower in the presence of alcohol, and more will remain in the blood. The alcohol makes the Valium more dangerous.

There is an interesting a genetic analogy. Asians are more likely to have a genetic variant of CYP2C19, which makes it less efficient in the metabolism of a number of drugs, including Valium (10). So it is not surprising that there is a rule of thumb when prescribing benzodiazepines to Asian people: “Start low and go slow.”

The other reason that alcohol and Valium can be deadly is the same reason that opioids and Valium are. It is physiological, not pharmacological. All three drugs depress respiration, and the effects are additive. The more drugs, the more the effect. This is probably at least as important as the drug-drug interactions in this case.

So, the take home message here is that while Valium on its own is quite safe (11) do NOT combine it with other drugs. Then it becomes anything but.

So, if you don’t get careless it is very unlikely that Valium will kill you. Don’t know if I can say the same for this article.

Notes:

(1) There are about 15 benzodiazepines available in the US. The major differences between them are how quickly they work and how long they stay in the body.

(2) This is a mish mash function of laws, insurance company restrictions, and pharmacy policies. In New York, CVS won’t let you order your Ambien online at one store and then switch the pickup to a more convenient store—something they routinely do for all prescriptions that are not scheduled. Or not. I was also told by them that it is left to the discretion of the individual pharmacist. Or maybe his dog. Yeah, go ahead and try to make sense out of this.

(3) The DEA keeps a 14-page list of scheduled drugs, should you have nothing better to do with your life.

(4) S.O.L. = Simply out of luck. Any of you who thought otherwise probably have dirty minds.

(5) What the graph doesn’t say is that the vast majority of benzodiazepine deaths result from the combination of these with other drugs or alcohol. The combination is the killer. The upward trend in deaths from 2000-2013 is unquestionably a result of the concurrent rise in opioid use during the same time period.

(6) Drug-drug interactions are defined as “The combined effect of drugs taken concurrently. The result may be antagonism or synergism and may be lethal in some cases.”

(7) Other chemist duties include: Dressing like you ran out of a burning hotel room (and thinking you look fine), pocket pen holders are no longer required, but recommended, and, unfortunately these days, looking for a job. Having things hanging out of your nose is optional. Chemists are not a glamorous bunch.

(8) The mechanism that causes these interactions is the same one makes grapefruit juice plus certain drugs a bad idea. The offending chemicals in grapefruit juice are called furanocoumarins. The are also CYP inhibitors.

(9) The suffix -azole is a dead giveaway. They are not only very likely to be anti-fungal drugs, but also belong to the subclass of antifungals that is the worst offender—the azoles.

(10) Some Asian people have a “double whammy,” and it’s all about genetics. A large percentage (about half, depending on geography) have low levels of the enzyme acetaldehyde dehydrogenase, which is responsible for the second of two steps in the metabolism of alcohol. When step #2 does not occur, acetaldehyde, which is quite toxic, accumulates, and this makes you quite ill. Some Asian people cannot drink any alcohol at all because of this.

(11) Safe as used in this article refers to acute dosages. Other factors such as dependency and addiction, and withdrawal are issue that are not relevant to this discussion.

Diazepam (Oral Route) Proper Use

Proper Use

Drug information provided by: IBM Micromedex

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole. Do not crush, break, or chew it.

To use the oral solution:

Measure the oral liquid with the medicine dropper that comes from the package.

Mix each dose with water, juice, soda or a soda-like beverage before you take it. You may also mix the liquid with a semisolid food such as applesauce or pudding.

Take the entire mixture right away. It should not be saved to use later.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (solution or tablets): For anxiety: Adults—2 to 10 milligrams (mg) 2 to 4 times a day. Older adults—At first, 2 to 2.5 mg 1 or 2 times a day. Your doctor may increase your dose if needed. Children 6 months of age and older—At first, 1 to 2.5 mg 3 or 4 times per day. Your child’s doctor may increase the dose if needed. Children up to 6 months of age—Use is not recommended. For alcohol withdrawal: Adults—10 milligrams (mg) 3 or 4 times for the first 24 hours, then 5 mg 3 to 4 times per day as needed. Older adults—At first, 2 to 2.5 mg 1 or 2 times a day. Your doctor will gradually increase your dose as needed. Children—Use and dose must be determined by your doctor. For muscle spasm: Adults—2 to 10 milligrams (mg) 3 or 4 times a day. Older adults—At first, 2 to 2.5 mg 1 or 2 times a day. Your doctor may increase your dose if needed. Children 6 months of age and older—At first, 1 to 2.5 mg 3 or 4 times per day. Your child’s doctor may increase the dose if needed. Children up to 6 months of age—Use is not recommended. For seizures: Adults—2 to 10 milligrams (mg) 2 to 4 times a day. Older adults—At first, 2 to 2.5 mg 1 or 2 times a day. Your doctor may increase your dose if needed. Children 6 months of age and older—At first, 1 to 2.5 mg 3 or 4 times per day. Your child’s doctor may increase the dose if needed. Children up to 6 months of age—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

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Valium (Diazepam Tablets): Uses, Dosage, Side Effects, Interactions, Warning

PATIENT INFORMATION

Diazepam

(dye-AZ-e-pam) 10 mg Tablets

What is the most important information I should know about diazepam tablets?

Diazepam tablets are a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, breathing problems (respiratory depression), coma and death.

Diazepam tablets can make you sleepy or dizzy, and can slow your thinking and motor skills.

Do not drive, operate heavy machinery, or do other dangerous activities until you know how diazepam tablets affect you.

Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking diazepam tablets without first talking to your healthcare provider. When taken with alcohol or drugs that cause sleepiness or dizziness, diazepam tablets may make your sleepiness or dizziness much worse.

Do not take more diazepam tablets than prescribed.

What are diazepam tablets?

Diazepam tablets are a prescription medicine used:

to treat anxiety disorders

for the short-term relief of the symptoms of anxiety

to relieve the symptoms of alcohol withdrawal including agitation, shakiness (tremor), sudden and severe mental or nervous system changes (delirium tremens) and seeing or hearing things that others do not see or hear (hallucinations)

along with other medicines for the relief of muscle spasms

along with other medicines to treat seizure disorders

Diazepam tablets are a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep diazepam tablets in a safe place to prevent misuse and abuse. Selling or giving away diazepam tablets may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs.

It is not known if diazepam tablets are safe and effective in children under 6 months of age.

It is not known if diazepam tablets are safe and effective for use longer than 4 months.

Do not take diazepam tablets if you:

are allergic to diazepam or any of the ingredients in diazepam tablets. See the end of this Medication Guide for a complete list of ingredients in diazepam tablets.

have a disease that can cause muscle weakness called myasthenia gravis

have severe breathing problems (severe respiratory insufficiency)

have severe liver problems

have a sleep problem called sleep apnea syndrome

Before you take diazepam tablets, tell your healthcare provider about all of your medical conditions, including if you:

have or have had depression, mood problems, or suicidal thoughts or behavior

have lung disease or breathing problems

have liver or kidney problems

are pregnant or plan to become pregnant. Diazepam tablets may harm your unborn baby. You and your healthcare provider should decide if you should take diazepam tablets while you are pregnant.

are breastfeeding or plan to breastfeed. Diazepam passes into your breast milk and may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take diazepam tablets. Do not breastfeed while taking diazepam tablets.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking diazepam tablets with certain other medicines can cause side effects or affect how well diazepam tablets or the other medicines work. Do not start or stop other medicines without talking to your healthcare provider.

How should I take diazepam tablets?

Take diazepam tablets exactly as your healthcare provider tells you to take them. Your healthcare provider will tell you how many diazepam tablets to take and when to take them.

Talk to your healthcare provider about slowly stopping diazepam tablets to avoid withdrawal symptoms.

If you take too many diazepam tablets, call your healthcare provider or go to the nearest hospital emergency room right away.

What should I avoid while taking diazepam tablets?

Diazepam tablets can cause you to be drowsy. Do not drive a car or operate heavy machinery until you know how diazepam tablets affect you.

You should not drink alcohol while taking diazepam tablets. Drinking alcohol can increase your chances of having serious side effects.

What are the possible side effects of diazepam tablets?

Diazepam tablets may cause serious side effects, including:

See â€œWhat is the most important information I should know about diazepam tablets?â€

Seizures . Taking diazepam tablets with other medicines used to treat epilepsy can cause an increase in the number or severity of grand mal seizures.

. Taking diazepam tablets with other medicines used to treat epilepsy can cause an increase in the number or severity of grand mal seizures. Withdrawal symptoms . You may have withdrawal symptoms if you stop taking diazepam tablets suddenly. Withdrawal symptoms can be serious and include seizures. Mild withdrawal symptoms include a depressed mood and trouble sleeping. Talk to your healthcare provider about slowly stopping diazepam tablets to avoid withdrawal symptoms.

. You may have withdrawal symptoms if you stop taking diazepam tablets suddenly. Withdrawal symptoms can be serious and include seizures. Mild withdrawal symptoms include a depressed mood and trouble sleeping. Talk to your healthcare provider about slowly stopping diazepam tablets to avoid withdrawal symptoms. Like other antiepileptic drugs, diazepam tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call your healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

thoughts about suicide or dying

new or worse anxiety

trouble sleeping (insomnia)

acting on dangerous impulses

attempts to commit suicide

feeling agitated or restless

new or worse irritability

an extreme increase in activity and talking (mania)

new or worse depression

panic attacks

acting aggressive, being angry, or violent

other unusual changes in behavior or mood

How can I watch for early symptoms of suicidal thoughts and actions?

Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.

Keep all follow-up visits with your healthcare provider as scheduled.

Call your healthcare provider between visits as needed, especially if you are worried about symptoms. Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

Abuse and dependence. Taking diazepam tablets can cause physical and psychological dependence. Physical and psychological dependence is not the same as drug addiction. Your healthcare provider can tell you more about the differences between physical and psychological dependence and drug addiction.

The most common side effects of diazepam tablets include:

drowsiness

muscle weakness

fatigue

loss of control of body movements (ataxia)

These are not all the possible side effects of diazepam tablets. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Teva Pharmaceuticals USA, Inc. at 1-866-832-8537.

How should I store diazepam tablets?

Store diazepam tablets in a tightly closed container between 68Â°F to 77Â°F (20Â°C to 25Â°C) and out of the light.

Keep diazepam tablets and all medicines out of the reach of children.

General information about the safe and effective use of diazepam tablets.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use diazepam tablets for a condition for which they were not prescribed. Do not give diazepam tablets to other people, even if they have the same symptoms that you have. They may harm them. You can ask your pharmacist or healthcare provider for information about diazepam tablets that is written for health professionals.

What are the ingredients in diazepam tablets?

Active ingredient: diazepam

Inactive ingredients: anhydrous lactose, colloidal silicon dioxide; colorants: 5 mg only (D&C Yellow No. 10 aluminum lake and FD&C Yellow No. 6); 10 mg only (FD&C Blue No. 1 aluminum lake); magnesium stearate, microcrystalline cellulose, pregelatinized corn starch, and sodium starch glycolate

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Top 18 How Much Valium Can Kill You The 30 Detailed Answer

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How long does 5mg diazepam last?

How long does it take for a 5mg diazepam to work?

Is 5mg diazepam side effects?

Is diazepam 5 mg a sleeping pill?

Can Valium Kill You? | American Council on Science and Health

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