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Table of Contents
How do you make a real heart model?
- Fill the mason jar about ⅔ full with water.
- Add red food coloring and mix.
- Cut the neck off the balloon.
- Stretch the body of the balloon over the opening of the jar. …
- Cut two small holes in the balloon. …
- Slide the small water balloon onto the end of one of the straws.
What would a model of the human heart be useful for studying?
Harvard University researchers have bioengineered a three-dimensional model of a human left heart ventricle that could be used to study diseases, test drugs and develop patient-specific treatments for heart conditions such as arrhythmia.
How does the heart model work?
Chambers fill with blood, then squeeze to pump the blood out. Each side of the heart has an entry chamber ( atrium ) and an exit chamber ( ventricle ). These pump one after the other to keep the blood flowing around. Valves stop blood flowing backwards.
A 3-D model of a human heart ventricle
The heart has two functions that ensure blood flows in the right direction. These are chambers and valves. The chambers fill with blood and then squeeze to pump the blood out.
Each side of the heart has an entry chamber (atrium) and an exit chamber (ventricle). These pump in sequence to keep the blood circulating.
Valves prevent blood from flowing back. When the ventricle contracts, the atria’s exit valve closes, preventing blood from flowing backwards. When the ventricle relaxes, its exit valve closes to stop the backflow of blood.
You can easily create a model of a chamber and valve to show how they work.
How do I make a heart model?
A clean, clear glass
1 balloon
water
food coloring
2 plastic straws
food coloring
tape
scissors
tray
Fill the jar a little more than half full and add a few drops of food coloring.
Cut off the neck of the balloon and stretch the rest over the opening of the jar. Save the balloon neck.
Use the scissors to carefully poke two holes in the balloon. These should be smaller than the straw as they need to be snug.
Put each straw through a hole in the balloon.
Place the neck of the balloon over the end of a straw and
Seal the end of a straw to the balloon neck and secure with tape. This is your valve.
Press the balloon and watch what happens. Water should be squeezed out of the straw that is not sealed.
The balloon end valve prevents water from flowing back into the straw.
Take the balloon valve from the straw. You should find that the water is now flowing back into the straw.
When you press on the balloon, it’s like your heart is contracting and the ventricles are squeezing. This forces blood from the heart into the arteries.
More experiments on the science of the human body
If you enjoyed this activity, we have many more body science experiments to try.
Listen to your heart with this super easy homemade stethoscope.
This digestive model is great messy fun and a fantastic way to demonstrate the journey of food through the human body.
Learn about the different parts of the brain and their functions with our easy putty brain model.
Learn more about blood with these fun blood-themed activities.
Science books for children
Don’t forget we also have a few science books for kids available in bookstores in the US and Amazon in the UK.
Last updated on September 23, 2021 by Emma Vanstone
Which kind of model would you use to represent a human heart?
What kind of model would you use to represent a human heart? A physical model.
A 3-D model of a human heart ventricle
How do you make a human heart?
- Create the heart using red playdough. …
- Attach a small tube of red playdough to the top of the right ventricle. …
- Connect a 1⁄2 inch (1.3 cm) tube vertically to the bottom of the heart. …
- Attach 3 small 1⁄4 inch (0.64 cm) tubes to the aorta. …
- Run a tube of blue playdough right across the aorta.
A 3-D model of a human heart ventricle
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Article overview
X
To make a model of a heart using playdough, take some red playdough and roll it into a ball about 1-1.5 inches wide. Using your fingers, shape the ball into the shape of an apple, making a slight indentation in the center to form two bulges. To make the aorta, roll a tube shape in red plasticine about 2 inches long and attach to the top of the left bulge. Use more red plasticine to add details like the arteries that come out from the aorta. Then use blue clay to make a tube that will be the left vein of your heart, as well as small tubes for the arteries. Use a sculptor’s knife for the small details. Read on to learn how to make a styrofoam heart model or a soda bottle and straw model!
How do you draw a human heart easily?
To draw a realistic human heart, start by making a shape like the bottom half of an acorn. This will form the main part of the heart. For extra realism, draw this shape so it’s tilted slightly to the left. Next, add a rounded bump to the top left side of the heart, which will represent the right atrium.
A 3-D model of a human heart ventricle
Article overview
X
To draw a realistic human heart, start by making a shape like the bottom half of an acorn. This will form the main part of the heart. For added realism, draw this shape so that it tilts slightly to the left. Next add a rounded bump on the upper left side of the heart, representing the right atrium. Although this may seem backwards, remember that you are drawing the heart in an anatomical position so the right side of the heart is on your left side. This shape should extend about halfway to the apex of the heart. Make a large tube coming out of the right atrium at the top. This tube is called the superior vena cava. Depending on how much of this you want to draw, you can either make a short single tube out of it, or go a little further and draw the two main branches that will fork out of it to form the right and left brachial veins. Next, draw a large tube in the shape of an inverted U, extending from the heart to the right of the right atrium. Make it a little wider than the superior vena cava. This large blood vessel is called the aorta. If you want extra detail add 3 smaller tubes protruding from the top of the aorta. Finally, make a third large tube, called the pulmonary artery, which wraps around to the left behind the aorta and to the right in front of it. Once you’ve sketched the main shapes, go back and fill in small details, like the spaces between the tubes and the blood vessels and fatty tissues that wrap around the heart’s main body. You can also color the heart in red and blue tones or add labels to identify the different parts of the heart or show the directions of blood flow in and out of the heart.
Life-Size Human Heart Anatomy Model
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Anatomical Human Life Size Heart Model Medical Cardiovascular Anatomy
Trụ sở chính: Tòa nhà Viettel, Số 285, đường Cách Mạng Tháng 8, phường 12, quận 10, Thành phố Hồ Chí Minh
Tiki nhận đặt hàng trực tuyến và giao hàng tận nơi, chưa hỗ trợ mua và nhận hàng trực tiếp tại văn phòng hoặc trung tự lým xử hng
Giấy chứng nhận đăng kinh doanh số 0309532909 do sở kế hoch và ầu tư thành phố chí minh cấp lầu ngày 06/01/2010 và sửa ổin ần thứ 23 ngày ổ ổi lần thứ ổi lần thứ ổi lần thứ ổi lần thứ ổi lần thứ.
© 2022 – Bản quyền của Công ty TNHH Ti Ki
How to Make a DIY Pumping Heart Model
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A 3-D model of a human heart ventricle
This three-dimensional model of a left ventricle of the heart was constructed using a nanofiber scaffold seeded with heart cells. It could be used to study diseases, test drugs and develop patient-specific treatments for heart conditions such as arrhythmia. (Luke MacQueen and Michael Rosnach/Harvard University)
This tissue-engineered ventricle, made from neonatal rat ventricular myocyte tissue, is spontaneously contracted, sutured, and attached to a catheter. (Luke MacQueen/Disease Biophysics Group/Harvard SEAS)
Harvard University researchers have bioengineered a three-dimensional model of a human left ventricle that could be used to study diseases, test drugs and develop patient-specific treatments for heart conditions such as arrhythmia.
The tissue is made with a nanofiber scaffold seeded with human heart cells. The scaffold acts like a 3D template, guiding the cells and their arrangement into the beating ventricular chambers in vitro. This allows researchers to study heart function using many of the same instruments used in the clinic, including pressure-volume loops and ultrasound.
The research was published in Nature Biomedical Engineering.
“Our group has spent more than a decade working toward the goal of building a whole heart, and this is an important step toward that goal,” said Kit Parker, professor of bioengineering and applied physics for the Tarr family of the Harvard John A. Paulson School of Engineering and Applied Sciences and senior author of the study. “The applications, from regenerative cardiovascular medicine to use as an in vitro model for drug discovery, are wide and varied.”
Parker also serves on the core faculty of Harvard’s Wyss Institute for Biologically Inspired Engineering, the Harvard Stem Cell Institute, and the Harvard Materials Research Science and Engineering Center.
The research was a collaboration between SEAS, Wyss, Boston Children’s Hospital and the Harvard Stem Cell Institute (HSCI).
“The long-term goal of this project is to replace or complement animal models with human models, and particularly patient-specific human models,” said Luke MacQueen, first author of the study and a postdoctoral fellow at SEAS and Wyss. “In the future, stem cells could be collected from patients and used to build tissue models that replicate some of the characteristics of their entire organ.”
“An exciting door is being opened to creating more physiological models of actual patient disease,” said William Pu, professor of pediatrics at Harvard Medical School and a senior faculty member at HSCI and a co-author of the publication. “These models share not only the patient’s mutations, but the entire genetic background of the patient.”
The key to building a functional ventricle lies in restoring the unique structure of the tissue. In native hearts, parallel myocardial fibers act as a scaffold, guiding brick-shaped heart cells to align and assemble end-to-end, creating a hollow, cone-shaped structure. When the heart beats, cells expand and contract like an accordion.
Pull-spinning a nanofiber ventricle scaffold. A polymer solution fed through a needle is drawn into a fiber by a bristle rotating at high speed. Fiber formation results from jet stretching and solvent evaporation, and the fibers are collected on a rotating ellipsoidal ventricle scaffold collector. (Disease Biophysics Group/Harvard SEAS)
To replicate this scaffold, the researchers used a nanofiber production platform called pull spinning, developed in Parker’s Disease Biophysics Group. In pull spinning, a high-speed rotating bristle is immersed in a polymer reservoir and a droplet of solution is drawn into a jet. The fiber moves in a spiral path and solidifies before detaching from the bristle and moving to a collector.
To create the ventricle, the researchers used a combination of biodegradable polyester and gelatin fibers collected on a rotating collector in the shape of a sphere. As the collector rotates, all of the fibers align in the same direction.
“It’s important to recap the structure of natural muscle to get ventricles that function like their natural counterparts,” MacQueen said. “When the fibers are aligned, the cells become aligned, which means they conduct and contract like native cells.”
After building the scaffold, the researchers cultured the ventricle with either rat myocytes or human cardiomyocytes from induced stem cells. Within three to five days, a thin wall of tissue covered the scaffold and the cells were beating synchronously. From there, researchers were able to control and monitor calcium proliferation and insert a catheter to study the pressure and volume of the beating chamber of the heart.
When the fibers are aligned, the cells become aligned, meaning they conduct and contract like native cells.
The researchers exposed the tissue to isoproterenol, a drug similar to adrenaline, and measured how the beating rate increased, just like human and rat hearts. The researchers also poked holes in the ventricle to mimic a myocardial infarction and studied the effects of the resulting heart attack in a Petri dish.
To better study the ventricle over long periods of time, researchers built a self-contained bioreactor with separate chambers for optional valve liners, additional catheter access ports, and optional ventricular assist features.
A self-contained bioreactor with separate chambers for optional valve liners, additional catheter access ports, and optional ventricular assist features. (John Ferrier/Harvard SEAS)
Using human induced stem cell-derived cardiomyocytes, the researchers were able to culture the ventricles for 6 months and measure stable pressure-volume loops. “The fact that we can study this ventricle over long periods of time is really good news for studying disease progression in patients and for drug therapies that take a while to work,” MacQueen said.
Next, the researchers aim to use patient-derived, pre-differentiated stem cells to seed the ventricles, which would allow higher-throughput production of the tissue.
“We started by learning how to build cardiac myocytes, then cardiac tissue, then muscle pumps in the form of marine organism mimics, and now a ventricle,” Parker said. “Along the way, we elucidated some of the fundamental laws of muscle pump construction and developed ideas for how the heart can be repaired when these laws are violated by disease. We still have a long way to go to build a four-chamber heart, but our progress is accelerating.”
The Harvard Office of Technology Development has protected intellectual property related to this project and is investigating commercialization opportunities.
This study was co-authored by Sean P Sheehy, Christophe O Chantre, John F Zimmerman, Francesco S Pasqualini, Xujie Liu, Josue A Goss, Patrick H Campbell, Grant M Gonzalez, Sung-Jin Park. Andrew K. Capulli, John P. Ferrier, T. Fettah Kosar and L. Mahadevan, Lola England de Valpine Professor of Applied Mathematics, Organismic and Evolutionary Biology and Physics.
This work was supported by the Harvard John A. Paulson School of Engineering and Applied Sciences at Harvard University, the Wyss Institute for Biologically Inspired Engineering at Harvard University, the Harvard Materials Research Science and Engineering Center, and subcontract to the Defense Threat Reduction Agency ( DTRA) from Los Alamos National Laboratory and the National Center for Advancing Translational Sciences of the National Institutes of Health.
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